Quiste dermoide latero cervical / Dermoid cyst of the lateral neck

Resumen Introducción: Los quistes dermoides son lesiones de origen ectodérmico poco frecuentes. Solo un 1,6% de ellos, se presenta en el piso de la boca y de éstos, solo un 6% lateralmente en el espacio submandibular. Objetivo: Reporte de caso y revisión de la literatura. Caso clínico: Se presenta un caso de una paciente de 32 años, con un cuadro de 1 año de evolución caracterizado por una lesión de crecimiento lento pero sostenido. Se le realizó la resección de la lesión junto con una submandibulectomía ipsilateral resultando compatible con un quiste dermoide. Discusión: La localización de esta lesión es muy infrecuente. En el estudio histopatológico son lesiones con epitelio pluriestratificado cornificado y anexos cutáneos. El estudio de imágenes orienta a una lesión quística, siendo la resonancia nuclear hoy en día el mejor examen para caracterizar esta lesión. Es una lesión benigna, sin recidivas reportadas cuando la resección ha sido completa.

Introduction: Dermoid cysts are uncommon lesions from ectodermic origin. Only 1.6% arise in the floor of the mouth, and at this site only 6% arise laterally in the submandibular region. Aim: Case report and review of the literature. Clinical Case: 32 years old patient, with a slow growing lesion during 1 year. Complete resection with an ipisilateral submandibulectomy was performed. The pathologic report showed a dermoid cyst. Discussion: The localization of this lesion is very uncommon. In the pathologic report are lesion with pluri stratified cornified epthitelium with skin attachments. Image studies show a cystic lesion being the magnetic resonance the best study to characterize this lesions. Are benign lesions, without recurrence reported when the lesion has been fully excised.

Proliferaciones Oncocíticas de Glándulas Salivales: Estudio Estructural e Inmunohistoquímico de 7 Casos / Oncocytic Proliferations of Salivary Glands: Structural and Immunohistochemical Study of 7 Cases

RESUMEN: Los oncocitos son células originadas probablemente por transformación metaplásica del epitelio ductal o acinar de parótida y submandibular. Su proliferación puede originar condiciones patológicas que incluyen hiperplasias oncocíticas adenomatosas multinodulares (HOAM), oncocitomas y carcinomas oncocíticos. Los tumores oncocíticos constituyen el 1 % de todos los tumores salivales y entre el 82 y 90 % se desarrollan en la parótida; el resto se divide entre la glándula submandibular y las glándulas salivales menores. Las hiperplasias oncocíticas multinodulares son extremadamente raras. En el presente trabajo se analizaron 5 casos de oncocitomas de parótida y dos casos de HOAM, uno de parótida y otro de submandibular y se describieron las características estructurales e inmunohistoquímicas de los oncocitos. Cortes seriados de las biopsias incluidas en parafina se colorearon con Hematoxilina - Eosina, Hematoxilina/ácido fosfotúngstico (PTA/H), PAS y se marcaron con AC antimitocondrial, CK 5/6, CK 20 y EMA. Los tumores mostraron un crecimiento nodular encapsulado por tejido conectivo denso. En los cortes histológicos se identificaron oncocitos eosinófilos (oscuros) y granulaciones violáceas con PTA/H. En dos casos de parótida y el caso de HOAM de submandibular presentaron además oncocitos claros PAS positivos. La inmunomarcación fue positiva en todas las células siendo la marcación para mitocondrias periférica en los oncocitos claros. Las células eosinofílicas PTA/H positivas y con fuerte marcación con AC antimitocondrial, CKs y EMA confirman el diagnóstico de patología oncocítica. En tres casos coexisten oncocitos claros y oscuros. Las células claras son oncocitos que acumulan glucógeno en su citoplasma desplazando a las mitocondrias hacia la periferia. En el diagnóstico diferencial de este tumor debemos considerar los tumores salivales con células claras, el carcinoma renal metastásico, el tumor de Whartin, la variante de células claras del carcinoma epitelial/mioepitelial y el carcinoma mucoepidermoide con metaplasia oncocítica.

ABSTRACT: Oncocytes are cells probably originated by metaplastic transformation of the ductal or acinar epithelium of parotid and submandibular. Its proliferation can cause pathological conditions that include multinodular adenomatous oncocytic hiperplasia (HOAM), oncocytomas and oncocytic carcinomas. Oncocytic tumors make up 1 % of all salivary tumors and between 82 and 90 % develop in the parotid; the rest of the tumors are divided between the submandibular gland and the minor salivary glands. Multinodular oncocytic hyperplasias are extremely rare. In the present work we analyzed five cases of parotid oncocytomas and two cases of HOAM, one of parotid and the other of submandibular; structural and immunohistochemical characteristics of the oncocytes were described. Biopsies were included in paraffin, serial cuts were stained with H&E, Hematoxylin / phosphotungstic acid (PTA / H), PAS and were marked with antimitochondrial AC, CK 5/6, CKs 20 and EMA. The tumors showed a nodular growth encapsulated by dense connective tissue. The histological cuts showed dark eosinophilic oncocytes and violaceous granulations with PTA / H. In two cases of parotid and the case of submandibular HOAM, PAS positive clear oncocytes were also present. The immunostaining was positive in all the cells, being the labeling for peripheral mitochondria in the clear oncocytes. Eosinophilic cells PTA / H positive with strongly marked with antimitochondrial AC, CKs and EMA confirm the diagnosis of oncocytic pathology. In three cases, light and dark oncocytes coexist. Clear cells are oncocytes that accumulate glycogen in their cytoplasm, displacing the mitochondria to the periphery. In the differential diagnosis we should consider salivary tumors with clear cells, metastatic renal carcinoma, Whartin's tumor, the clear cell variant of epithelial / myoepithelial carcinoma and mucoepidermoid carcinoma with oncocytic metaplasia.

A Case of Sebaceous Carcinoma of the Submandibular Gland / 대한이비인후과학회지

Sebaceous carcinoma of the salivary gland is an extremely unordinary malignancy occurring mainly in the parotid gland. Sebaceous carcinoma arising in the submandibular gland is exceptional and only three cases have been reported in the literature. We herein present a unique case of sebaceous carcinoma of the submandibular gland, the first to be reported in literature in South Korea. An 85-year-old man visited our hospital complaining of a progressively enlarging submandibular mass with tenderness and ipsilateral facial palsy. We performed a wide excision of the mass with superficial parotidectomy and modified neck dissection. Microscopic and immunohistochemical examinations demonstrated sebaceous carcinoma of low grade differentiation. Further adjuvant radiotherapy was rejected and the patient was followed up for five months. The optimal treatment of sebaceous carcinoma of the salivary gland is still not established due to the rarity of the disease. When more cases are reported, the clinicopathologic characteristics will be better understood.

Pleomorphic Adenoma in a Young Female: Case Report / Adenoma Pleomórfico en una Mujer Joven: Reporte de Caso

ABSTRACT: Pleomorphic adenoma (PA) is the most common benign salivary gland neoplasm and it is frequently diagnosed in the third and fourth decade with predilection for women. PA is the most common benign lesion of minor salivary glands in children and adolescents, being the palate one of the most frequently affected site of minor salivary glands. Herein, we present a case report of a PA of the hard palate diagnosed in a 15-year-old female and a review of the Englishliterature of the reported cases of PA in children and adolescents in the hard palate.

RESUMEN: El adenoma pleomórfico (AP) es la neoplasia benigna más común de las glándulas salivales y se diagnostica frecuentemente en la tercera y cuarta década con predilección por las mujeres. El AP es la lesión benigna más común de las glándulas salivales menores en niños y adolescentes, siendo el paladar uno de los sitios más frecuentemente afectados de las glándulas salivales menores. En este trabajo se presenta un relato de caso de un AP de paladar duro diagnosticado en una mujer de 15 años de edad y una revisión de la literatura en inglés de los casos reportados de AP en niños y adolescentes en paladar duro.

Sialolitos na glândula submandibular: relato de caso / Sialolitos the submandibular gland: a case report

A sialolitíase é uma alteração de glândula salivar que se caracteriza pela deposição de sais de cálcio dentro do ducto de uma glândula, ou mesmo no seu parênquima. A hipótese etiológica mais aceita é a de que os sialolitos se originam da deposição de sais de cálcio ao redor de restos orgânicos acumulados no interior do ducto, que por sua vez podem resultar de fatores como infecções, traumas, presença de corpos estranhos e de células epiteliais descamadas, além disso, a glândula mais atingida é a submandibular pela sua posição anatômica e composição salivar. O diagnóstico é feito através de exames clínicos e imaginológicos e o tratamento vai depender do tamanho e da localização do sialolito, podendo variar de estimulação da saliva até a remoção cirúrgica da glândula envolvida. Este estudo objetiva relatar um caso clínico de um paciente com dois cálculos presentes no ducto e um cálculo presente no parênquima da glândula submandibular. O tratamento proposto foi a cirurgia de exérese intraoral dos cálculos ductais e extra oral da glândula submandibular direita juntamente com o seu sialolito

The sialolithiasis is a change in salivary gland which is characterized by the deposition of calcium salts within the duct of a gland or the parenchyma. The etiological most widely accepted hypothesis is that the sialolitos arise from deposition of calcium salts accumulated around inside the duct, which in turn can result from factors such as infection, trauma, foreign bodies and cell debris organic desquamated epithelial furthermore, more submandibular gland is achieved by its anatomical position and salivary composition. Diagnosis is by clinical examination and imaging and treatment will depend on the size and location of sialólito, ranging from stimulation of saliva to the surgical removal of the gland involved. This study aims to report a case of a patient with two calculations present in the duct and a present in the parenchyma of the submandibular gland calculus. The proposed treatment was surgical excision of ductal intra oral and extra oral calculations of the right submandibular gland along with its sialolito

Metástasis a la glándula submandibular por carcinomas escamosos de cabeza y cuello: ¿mito o realidad? / Metastasis to the submandibular gland in head and neck squamous cell carcinomas: Myth or reality?

Introducción: muy pocos estudios se han publicado respecto a la posibilidad de metástasis a la glándula submandibular por carcinomas escamosos de cabeza y cuello. Objetivo: identificar la evidencia científica más reciente respecto a la posibilidad de metástasis a la glándula submandibular por carcinomas escamosos de cabeza y cuello. Métodos: se realizó un estudio metaanalítico mediante una búsqueda retrospectiva de artículos publicados en las bases de datos electrónicas PUBMED, MEDLINE, COCHRANE, HINARI desde 2003 hasta 2013; en las revistas Acta of Otolaryngology, Journal of Otolaryngology, Journal of Laryngology and Otology, Journal of Cranio­Maxillo Surgery, International Journal of Oral and Maxillofacial Surgery, Head and Neck, Annals of Surgical Oncology con los términos: metástasis por carcinomas escamosos de cabeza y cuello, metástasis a glándulas salivales, metástasis a la glándula submandibular, tumores malignos de glándula submandibular sin restricciones idiomáticas. Además de cumplir con estos requisitos se incluyeron solo los artículos cuyo material y método reflejara: cirugía y disecciones linfonodulares cervicales como primer tratamiento oncológico específico; estudio anatomopatológico para concluir el diagnóstico y discusión del estudio donde quedara explícita la opinión de los autores. Se incluyeron artículos publicados durante los últimos 10 años. Análisis e integración de la información: el estudio metaanalítico de 12 series de pacientes con carcinomas de cabeza y cuello conformó una metapoblación de 2 483 pacientes. Solo hubo 3 casos de metástasis a la glándula submandibular, representando (0,12 por ciento del total), o sea, 1 de cada 827 presentó metástasis a esta glándula. Una metamuestra de 848 glándulas se analizó dentro de las series en que fueron reportadas y solo 0,35 por ciento presentó metástasis. Conclusión: el presente estudio sugiere que los carcinomas de cabeza y cuello metastizan a la submandibular con una frecuencia casi nula, lo que pudiera sugerir su preservación de la submandibular en las disecciones cervicales linfonodulares(AU)

Introduction: very few studies have been published about the possibility of metastasis to the submandibular gland in head and neck squamous cell carcinomas. Objective: identify the latest scientific evidence about the possibility of metastasis to the submandibular gland in head and neck squamous cell carcinomas. Methods: a meta-analytical study was conducted based on a retrospective search of papers published in the databases PUBMED, MEDLINE, COCHRANE and HINARI from 2003 to 2013, as well as in the journals Acta of Otolaryngology, Journal of Otolaryngology, Journal of Laryngology and Otology, Journal of Cranio-Maxillo Surgery, International Journal of Oral and Maxillofacial Surgery, Head and Neck, and Annals of Surgical Oncology, using the following search terms: metastasis from head and neck squamous cell carcinomas, metastasis to salivary glands, metastasis to the submandibular gland and malignant tumors of the submandibular gland, without any language restrictions. Papers were selected which met the above criteria and referred to the following contents in their materials and methods section: cervical lymph node surgery and dissection as the first onco-specific treatment, anatomopathological study to complete the diagnosis, and a clear statement of the authors opinions in the discussion of the study. The papers included had been published in the previous 10 years. Data analysis and integration: a meta-analytical study was conducted of 12 series of patients with head and neck carcinomas for a metapopulation of 2 483 patients. Only 3 cases were found of metastasis to the submandibular gland, representing 0.12 percent of the total cases, that is, 1 for every 827 cases. A meta-sample of 848 glands were analyzed within the series in which they were reported, and only 0.35 percent presented metastasis. Conclusion: the study suggests that head and neck carcinomas metastasize to the submandibular gland with an almost null frequency, which may point to the preservation of the submandibular gland in cervical lymph node dissections(AU)

Submandibular gland excision / Ressecção da glândula submandibular

OBJECTIVE: To analyze the value of fine needle aspiration and the rates of postoperative complications in patients undergoing resection of the submandibular gland. METHODS: we analyzed the records of patients treated with resection of the gland from January 1995 to December 2008. The data collected included age, gender, findings on clinical history, surgical procedure, results of fine needle aspiration (FNA), pathological diagnosis and complications. RESULTS: 117 patients were studied, aged 12-89 years (mean 48), 70 women and 47 men. Thirty-nine patients (33.3%) were affected by inflammatory diseases (28 patients with lithiasis), 70 had benign tumors, and malignant tumors, eight. Regarding FNA, the sensitivity and specificity were 85.7% and 100%, respectively. Nine patients (7.7%) had temporary paralysis of the marginal mandibular nerve and one had permanent paralysis. CONCLUSION: resection of the submandibular gland is a safe procedure, with low complication rates.

OBJETIVO: Analisar o valor da punção aspirativa por agulha fina e os índices de complicações pós-operatórias em pacientes submetidos à ressecção da glândula submandibular. MÉTODOS: foram analisados os prontuários de pacientes tratados com a ressecção da glândula, de janeiro de 1995 a dezembro de 2008. Os dados coletados foram: idade, sexo, achados na história clínica, procedimento cirúrgico, resultados da punção por aspiração com agulha fina (PAAF), diagnóstico anatomopatológico e complicações. RESULTADOS: foram estudados 117 pacientes, com idade variando de 12 a 89 anos (média, 48 anos), sendo 70 mulheres e 47 homens. Trinta e nove pacientes (33,3%) foram acometidos por doenças inflamatórias (28 pacientes com litíase), 70 tiveram tumores benignos e oito tumores malignos. A respeito da PAAF, a sensibilidade e especificidade foram de 85,7% e 100%, respectivamente. Nove pacientes (7,7%) tiveram paralisia temporária do nervo mandibular marginal e um apresentou paralisia definitiva. CONCLUSÃO: a ressecção da glândula submandibular é um procedimento seguro, com baixa taxa de complicações.

Schwannoma of submandibular gland: a case report / 临床耳鼻咽喉头颈外科杂志

A case of Schwannoma in the submandibular gland was reported which had been misdiagnosed as pleomorphic adenoma before operation. The tumor was originated from lingual nerve which in turn invaded the Schwann membrane near the submandibular ganglion.

Prise en charge des cancers primitifs des glandes submandibulaires

Introduction :Les tumeurs malignes de la glande submandibulaire se caracterisent par une grande diversite histologique. de ce travail est de rapporter notre experience dans la prise en charge de ces tumeurs et de suggerer une attitude therapeutique apres revue de la litterature. Patients et methode : Il s'agit d'une etude retrospective a propos de 20 patients colliges sur 17 ans. La decision therapeutique etait prise au sein d'un comite multidisciplinaire. Les moyens therapeutiques etaient la chirurgie tumorale et ganglionnaire; la radiotherapie et la chimiotherapie. Les pieces operatoires ont ete adressees pour examen anatomopathologique extemporane et definitif. Une surveillance clinique et radiologique a ete realisee. Le recul moyen etait de 35 mois. Resultats: L'age moyen etait de 60;75 ans. Le delai moyen de consultation etait de 6;15 mois. La tumefaction submandibulaire etait le motif de consultation chez tous les patients. Des adenopathies cervicales etaient notees chez 8 patients (40). Seize patients avaient beneficie d'une tomodensitometrie cervicale et du massif facial et un autre d'une Irm. La radiographie du thorax montrait un aspect de lacher de ballon chez un patient et une opacite mediastinale chez un autre. L'abstention chirurgicale avait ete decidee pour 2 patients. Les patients metastatiques ont ete operes uniquement dans un but diagnostique. Dix-huit patients (85) ont eu une submandibulectomie; dont une elargie a la mandibule. Pour le geste ganglionnaire; 11 patients ont eu un curage selectif triangulaire et 3 un curage fonctionnel complet. Une radiotherapie postoperatoire a ete realisee chez 14 patients (70). Une radiotherapie palliative isolee a ete realisee chez 2 patients. Une chimiotherapie palliative a ete indiquee chez les 2 patients presentant des metastases a distance lors du diagnostic; mais n'a ete administree que dans un cas. La remission complete etait notee dans 11 cas (55). Un seul patient avait presente une poursuite evolutive. Une recidive loco-regionale avait ete decelee chez 2 patients. Deux patients avaient developpe secondairement des metastases a distance. Le taux de mortalite dans notre serie etait de 25. Conclusion: Les cancers de la glande submandibulaire representent une pathologie peu frequente. Le diagnostic a grandement beneficie de l'apport de l'imagerie. La strategie therapeutique depend du stade tumoral au moment du diagnostic et de l'etat general du patient. Le pronostic de ces tumeurs reste toujours reserve; surtout pour les tumeurs de haut grade diagnostiquees a un stade avance

Lymphoepithelial carcinoma in salivary glands: clinical and pathological analysis of 17 cases / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#Lymphoepithelial carcinoma (LEC) of salivary glands is a rare malignant neoplasm. The purpose of this research was to investigate the clinicalpathologic features and treatment methods of this rare disease.@*METHOD@#The clinical data and treatment outcomes of 17 patients from 2006 to 2012 were reviewed retrospectively.@*RESULT@#Ten males and seven females with a ratio of 1. 43:1 were involved. The II, III, IV stage cases were 7 (41.2%), 4 (23.5%), 6 (35.3%), respectively. The average follow-up duration was 2.56 years, and 12 patients had no evidence of recurrence. Five patients had local recurrence and (or) distant metastases within three years after surgery, including 4 deaths.@*CONCLUSION@#LEC in salivary gland is a high grade malignant tumor in oral and maxillofacial region, occurring predominately in parotid gland and submandibular gland. To prevent distant metastasis, radical surgery combined with chemoradiotherapy should be adopted.

Unusual Case of Sialoangiolipoma.

Sialoangiolipoma is extremely rare in adults. We report a case with an extremely unusual and atypical presentation of sialangolipoma of submandibular gland. The diagnosis of which is done on histopathology in a case with high index of clinical suspicion of pleomorphic adenoma.

Mucoepidermoid carcinoma of the submandibular gland in a 6yr old boy

Mucoepidermoid carcinoma [MEC] of the salivary glands are rarely found in childhood we report the case of a 6-year old boy presenting with 2-month history of submandibular swelling. In oral examination, a non-tender, firm mass was detected in the submandibular region involving the left cheek and left angle of the mandible. It was firm in consistency with obvious areas of multiple nodularity along the inferior border of the mass. Clinically there were no palpable lymph nodes. Radiographs revealed a radiolucent lesion in the left body of the mandible. The tumor showed sheets and nests of predominantly epidermoid cells along with occasional large pale mucous-like cells and frosted-glass appearance infiltrating the fibro-connective tissue. The lesion was diagnosed as mucoepidermoid carcinoma, high grade type

A Case of Oncocytic Carcinoma Arising in the Submandibular Gland / 대한이비인후과학회지

Oncocytic neoplasm of the head and neck region accounts for approximately 1% of all salivary gland tumors, but only 5% of oncocytic neoplasm is malignant. Oncocytic carcinoma arising in the submandibular gland is exceedingly rare. We encountered a sixty seven-year-old male patient who presented with multiple mass in the right neck. Fine needle aspiration biopsy revealed a salivary gland tumor of predominantly oncocytic form, and a differential diagnosis included oncocytic adenoma or mucoepidermoid carcinoma. A right submandibular gland resection and modified radical neck dissection were performed. Histologically, the tumor cells showed nuclear pleomorphism, and stromal invasion, which were compatible with oncocytic carcinoma. After surgery, the entire neck region was irradiated. Seventeen months after the initial surgery, multiple metastases to the bone and lung were detected from the incidental pathologic bone fracture of the right humerus; palliative chemotherapy was performed to resolve this. We report a case of oncocytic carcinoma in the submandibular gland with a review of literature.

Salivary gland diseases: analysis of patients attended at dow lab Karachi

The aim of this study is to describe demographic characteristic of 103 cases of major and minor salivary glands diagnosed at DDRRL [Dow lab Diagnostic reference and research laboratory] OJHA campus, DUHS Karachi. Observational Study. This study was conducted at Dow University of Health Sciences Ojha Campus, Karachi from January 2009 to April 2011. Salivary gland diseases are uncommon and include diseases which affect both major and minor salivary gland. They consist of a group of heterogeneous lesions with complex clinicopathological characteristics and distinct biologic behavior. Epidemiological data of these diseases in the various parts of the world can be helpful for a better understanding of its biology and clinical characteristics. Clinical and histopathological data of all patients with salivary gland diseases are retrospectively analyzed and described. In this study, 103 cases of salivary gland diseases be analyzed, out of all cases 31 were infections, 50 were benign neoplasms, and 22 were malignant neoplasms. Majority of the cases occurred in parotid gland followed by submandibular and minor salivary glands. Infections are common between the ages between 10-35 years and peak incidence in 30 years. Benign tumors are common between 20-25 years and 40-50 years and with a peak incidence in 40 years. Tumor affected more commonly the adult patients with peak incidence between 35065 years and peak incidence in 50 years with slight predominance in females. Pleomorphic adenoma is the most frequent finding followed by sialadenitis and squamous cell carcinoma. patients with salivary gland diseases were mainly adults with marginally more female patients. Most commonly found infections are sialadenitis involving sub mandibular gland in majority of cases. Benign tumors are more frequent then malignant ones. Pleomorphic adenoma is the commonest benign tumor and squamous cell carcinoma is the commonest malignant neoplasm. Both benign and malignant tumors involve parotid gland commonly

Submandibular mass excision in an Asian population: a 10-year review

<p><b>OBJECTIVES</b>The objectives of this study were to compare the prevalence of submandibular gland neoplasia in an Asian population with a Western population and to evaluate the accuracy of fi ne needle aspiration cytology (FNAC) and computed tomography (CT) scan in the study of submandibular gland pathologies.</p><p><b>MATERIALS AND METHODS</b>We conducted a 10-year retrospective review of 101 submandibular mass excisions. Data on the demographic profi le of patients, clinical features, correlation of fi ne needle aspiration cytology, CT scans and histology and morbidities related to surgery were collected.</p><p><b>RESULTS</b>The prevalence of submandibular gland neoplasia was 27.1%. Most (78.9%) of these were benign. FNAC and CT scans were accurate for benign neoplasia. However, the accuracy of FNAC and CT scans for sialadenitis without sialolithiasis was low.</p><p><b>CONCLUSION</b>The prevalence of submandibular gland malignancy was lower in the Asian population. FNAC and CT scans were accurate for benign neoplasia of the submandibular gland.</p>

Tumours of the submandibular salivary gland: a clinicopathologic review of cases over a 17-year period / Tumores de la glándula salival submandibular: una revisión clínico-patológica de casos por un período de 17 Años

OBJECTIVE: This study presents a clinicopathologic review of cases of submandibular salivary gland tumours at the Lagos University Teaching Hospital, Nigeria, over a period of 17 years. METHODS: The records of all patients with histological diagnosis of submandibular salivary gland tumours at the Lagos University Teaching Hospital over a period of 17 years (January 1990 to December 2006) were retrospectively reviewed. Parameters studied were; age and gender of patients, symptoms and duration ofsymptoms, and histological diagnosis. RESULTS: A total of 36patients with submandibular gland tumours were seen during the period. Maleto-female ratio was 1.8:1 (male = 23, female = 13). Mean age (± SD) at presentation was 43 (± 19) years (age range, 17-84 years). There were 19 malignant tumours and 17 benign ones. Pleomorphic adenoma (36.1%) was the most frequent tumours, followed by adenoid cystic carcinoma (11.1%), anaplastic carcinoma (11.1%) and malignant lymphoma (11.1%). Patients with histological diagnosis of malignant tumours were significantly older than those with benign tumours (p = 0.01). Most patients (80.6%) presented with painless swelling. CONCLUSION: Malignant submandibular salivary gland tumours were slightly more than the benign ones in the studied population. Painful swelling or ulceration is indicative ofa malignant submandibular gland tumour.

OBJETIVO: Este estudio presenta una revisión clinicopatológica de casos de tumores de la glándula salival submandibular en el Hospital Docente de la Universidad de Lagos, Nigeria, por un periodo de 17 años. MÉTODOS: Se revisaron retrospectivamente las historias clínicas de todos los pacientes con el diagnóstico histológico de los tumores de la glándula salival submandibular en el Hospital Docente de la Universidad de Lagos, correspondientes a un periodo de 17 años (de enero de 1990 a diciembre de 2006). Los parámetros estudiados incluyeron: la edad y el género de los pacientes, síntomas y duración de síntomas, y diagnóstico histológico. RESULTADOS: Un total de 36 pacientes con tumores de la glándula de submandibular fueron atendidos durante ese periodo. La proporción varón:hembra fue 1.8:1 (varones = 23, hembras = 13). La edad promedio (± SD) al momento de su presentación fue 43 (± 19) años (rango de edad, 17-84 años). Hubo 19 tumores malignos y 17 benignos. El adenoma pleomórfico (36.1%) fue el tipo de tumor más frecuente, seguido por el carcinoma cístico adenoideo (11.1%), el carcinoma anaplástico (11.1%) y el linfoma maligno (11.1%). Los pacientes con diagnóstico histológico de tumores malignos eran significativamente de más edad que los que tenían tumores benignos (p = 0.01). La mayoría de los pacientes (80.6%) presentaban hinchazón sin dolor. CONCLUSIÓN: Los tumores malignos de la glándula salival submandibular fueron ligeramente mayor en número que los benignos en la población estudiada. Hinchazón dolorosa o la ulceración dolorosas son indicios de un tumor maligno de la glándula submandibular.

Teratoma congénito de origen intracraneano / Congenital Intracranial Teratoma

Los teratomas son tumores de origen embrionario asociados con mal pronóstico en cualquier etapa de la vida en que se presenten. Reportamos un caso recibido en el Departamento de Patología del Hospital Universitario San Ignacio: feto femenino con masa tumoral en región submandibular derecha dependiente del lóbulo temporal cerebral derecho, con el cual se comunica a través del esfenoides ipsilateral. Histológicamente se diagnosticó teratoma inmaduro del sistema nervioso central. La mayor dificultad diagnóstica se presentó en la graduación de inmadurez, por corresponder a un feto, cuyos tejidos son, de por sí, inmaduros.

Teratomas are embyonic tumors associated with erroneous prognosis at any life stage. We report on a case from the Department of Pathology, San Ignacio University Hospital, Bogota: a female fetus with tumoral mass in the right submandibular region within the right cerebral temporal lobule linked through the ipsilateral sphenoid. An immature teratoma of the central nervous system was histologically diagnosed. The major diagnostic difficulty encountered was determining degree of immaturity, due to the fact that fetal tissue is by definition immature.